Evaluate the Gln223Arg LEPR genotype variation in T2DM patients with chronic kidney disease
Yazarlar (5)
Shahab Ahmed Salıh Gezh
Dr. Öğr. Üyesi Figen GÜZELGÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Hakan ŞIVGIN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Köksal DEVECİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Obesity Medicine | ||
| Dergi ISSN | 2451-8476 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 56 / 100630 / 1–8 | DOI | 10.1016/j.obmed.2025.100630 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S2451847625000508?casa_token=7O1KQ2U5eOcAAAAA:-hFchhMO_lKxIyw6HIPq2I2J8LRm73UKR3Do4eZ2s0vSVCOqOUMonhrPoHw6bbrl4xL0SKphImE | ||
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| Özet |
| BackgroundObesity significantly contributes to the development of type 2 diabetes mellitus (T2DM). Genetic variations in leptin receptor (LEPR) genes are thought to be influential in the onset of T2DM in patients with kidney malfunction and obesity. This study focused on examining the link between the Gln223Arg polymorphism in the LEPR gene and T2DM in the mid-Black Sea region of the Anatolian Turkish population.MethodologyIn this study, we examined a group of 174 patients with T2DM and compared them to a control group of 30 healthy individuals to explore the relationship involving the leptin receptor gene (Gln223Arg). The T2DM group was divided into 91 patients with macroproteinuria and 46 patients with normoproteinuria subgroups. The genetic analysis was conducted using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique.ResultsOur data … |
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| Google Scholar | 1 |