Effects of interleukin IL 6 gene polymorphisms on recurrent aphthous stomatitis
Yazarlar (5)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Türkiye
Aydın Rüstemoğlu Türkiye
Göknur Kalkan Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Arch Dermatol Res. (Q2) | ||
| Dergi ISSN | 1432-069X Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2013 |
| Cilt / Sayı / Sayfa | 306 / 2 / 173–180 | DOI | 10.1007/s00403-013-1406 |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Recurrent aphthous stomatitis (RAS) is a common disease with oral ulceration in which cytokines are thought to play an important role. High levels of interleukin (IL)-6, a pro-inflammatory cytokine have been detected in the circulation of ulcer tissue. The purpose of the present study was to investigate if the IL-6 gene polymorphisms are associated with RAS or clinical characteristics of RAS in a cohort of Turkish population. 184 RAS patients and 150 healthy controls were included in the study. The genotypes of IL-6 gene −572G>C and −174G>C polymorphisms were determined using polymerase chain reaction based restriction fragment length polymorphism analysis. The genotype frequencies of −572G>C polymorphism showed statistically significant differences between RAS patients and controls (p = 0.01). Frequencies of GG + GC genotypes and G allele of −572G>C polymorphism were found higher in RAS … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Yöksis | 37 |
| Google Scholar | 58 |