MDR1 gene polymorphisms may be associated with Behçet s disease and its colchicum treatment response
Yazarlar (10)
Aydın Rüstemoğlu Türkiye
Ülker Gül Türkiye
Güvem Gümüş Akay Türkiye
Müzeyyen Gönül Türkiye
Prof. Dr. Serbülent Yiğit Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aynur Karadağ Gürel Türkiye
Emine Pişkin
Asuman Sunguroğlu Türkiye
Ahmet Kadıkıran Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | GENE (Q3) | ||
| Dergi ISSN | 0378-1119 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2012 |
| Cilt / Sayı / Sayfa | 505 / 2 / 333–339 | DOI | 10.1016/j.gene.2012.05.040. |
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| Behçet's disease (BD) is a chronic multisystem disorder. Infectious agents, immune system mechanisms, and genetic factors are implicated in the etiopathogenesis of BD, which remains to be explained. The human MDR1 (ABCB1) gene encoder P-glycoprotein (P-gp) plays a key role in drug disposition, serves as a protective mechanism against xenobiotics, and provides additional protection for the brain, testis, and fetus. We investigated the genotype and haplotype distributions of three MDR1 gene polymorphisms (C1236T, G2677T/A, and C3435T) in 104 BD patients and 130 control subjects. The genotyping analysis was performed by using PCR–RFLP methods. No statistically significant differences were found for the genotypic and allelic distributions of three individual single nucleotide polymorphisms (SNPs) in the MDR1 gene between BD patients and control subjects in this study (p>0.05). However … |
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BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Google Scholar | 24 |