The effects of trimetazidine and sildenafil on bilateral cavernosal nerve injury induced oxidative damage and cavernosal fibrosis in rats
Yazarlar (5)
Prof. Dr. Doğan ATILĞAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Bekir Süha PARLAKTAŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Nihat ULUOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret ERDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ünal Erkorkmaz Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | SCIENTIFIC WORLD JOURNAL | ||
| Dergi ISSN | 1537-744X Dergi Bilgileri (2014) | ||
| Dergi Tarandığı Indeksler | AHCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Cilt / Sayı / Sayfa | 18 / 0 / – | DOI | 10.1155/2014/970363 |
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| The aim of this study was to compare the effects of sildenafil and trimetazidine on bilateral cavernosal nerve injury-induced oxidative damage and fibrotic changes in cavernosal tissue in rat model. A total of 32 male Sprague-Dawley rats were randomly divided into 4 groups; each group consist 8 rats (control, BCI, BCI + TMZ, and BCI + sildenafil groups). Tissue superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) levels were determined biochemically and distribution of cavernosal fibrosis density among groups was performed histopathologically. Tissue SOD levels in BCI group were significantly lower than the control group (P < 0.05). Tissue MDA and PC levels in BCI group were significantly higher than the control group (P < 0.05). TMZ and sildenafil administration significantly increased tissue SOD levels (P < 0.05) and reduced tissue MDA and PC levels (P < 0.05). Histologically, the degree of cavernosal fibrosis and collagen density was higher in BCI group in comparison to control, TMZ-treated, and sildenafil-treated groups. BCI caused oxidative damage and increased cavernosal fibrosis in rat penis. TMZ and sildenafil treatment decreased oxidative damage and reduced the degree of fibrosis in penile tissue due to BCI. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 5 |
| Web of Science | 16 |