Pollutant-induced pyroptosis in humans and other animals
Yazarlar (2)
Dr. Öğr. Üyesi Çağlar BERKEL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ercan ÇAÇAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Life Sciences |
| Dergi ISSN | 0024-3205 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2023 |
| Cilt No | 316 |
| Sayı | 1 |
| DOI Numarası | 10.1016/j.lfs.2023.121386 |
| Makale Linki | https://www.sciencedirect.com/science/article/abs/pii/S0024320523000206 |
| Özet |
| Pyroptosis is a form of lytic cell death with pro-inflammatory characteristics, induced upon the activation of certain inflammatory caspases by inflammasome complexes such as NLRP3 inflammasome. Gasdermin proteins as the mediators of pyroptosis form cell membrane pores upon activation, which release certain cellular contents into the extracellular space including inflammatory cytokines such as IL-1β and IL-18, and also damage the integrity of the cell membrane. Gasdermins have been implicated in autoimmune and inflammatory diseases, infectious diseases, deafness and cancer. Mostly in the last 2 years, diverse pollutant types including particulate matter, cadmium and polystyrene microplastics were reported to induce pyroptotic cell death in diverse tissues from mammals to birds. In the present study, we review our current understanding of pollutant-induced pyroptosis as well as current knowledge of upstream events leading to pyroptotic cell death upon exposure to pollutants. |
| Anahtar Kelimeler |
| Cadmium | Caspase-1 | Cell death | Cytokines | Gasdermin | GSDMD | GSDME | Inflammasome | Inflammation | Microplastics | NLRP3 | Particulate matter | Pollutant | Polystyrene microplastics | Pyroptosis |
Science Direct
Pollutant-induced pyroptosis in humans and other animals
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 9 |
| Google Scholar | 10 |