Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M
Yazarlar (9)
Université Constantine 1, Cezayir
Université Constantine 1, Cezayir
Dr. Öğr. Üyesi Çağlar BERKEL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Université Constantine 1, Cezayir
Université Constantine 1, Cezayir
Université Constantine 1, Cezayir
Université Constantine 1, Cezayir
Prof. Dr. Ercan ÇAÇAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Université Constantine 1, Cezayir
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | Anti Inflammatory and Anti Allergy Agents in Medicinal Chemistry |
| Dergi ISSN | 1871-5230 Scopus Dergi |
| Dergi Tarandığı Indeksler | MEDLINE/PubMed, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, EMBASE/Excerpta Medica, Chemical Abstracts Service/SciFinder, ProQuest, ChemWeb, Google Scholar, PubsHub, MediaFinder®-Standard Periodical Directory, Genamics JournalSeek, J-Gate, CNKI Scholar, Suweco CZ, TOC Premier, EBSCO, British Library, Ulrich'xxs Periodicals Directory and JournalTOCs. |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2020 |
| Cilt No | 20 |
| Sayı | 1 |
| Sayfalar | 89 / 100 |
| DOI Numarası | 10.2174/1871523019666200609140532 |
| Özet |
| Background: In Algerian traditional medicine, Centaurea species are well known in traditherapy. Centaurea africana has been used in folk medicine for the treatment of several inflammatory disorders. Objective: This study aims to examine the antioxidant, anti-inflammatory and anti-proliferative potential of both n-Butanol (BECA) and ethyl acetate (EAECA) extracts of Centaurea africana. Methods: The phytochemical analysis of both BECA and EAECA were explored and the antioxidant activities were investigated by measuring the DPPH° scavenging effect, the reducing power and the inhibition of lipid peroxidation (LPO) induced by by Fe2+/ ascorbic acid system. The antiinflammatory properties were determined by measuring the NO° scavenging effect and by using carrageenan-induced rat paw oedema. The antiproliferative activity was studied on HT29 (human colorectal adenocarcinoma), OV2008 (human ovarian cancer) and C6 (Rattus norvegicus brain glioma) cell lines using the Sulforhodamine B assay. Results: The total polyphenol contents (TPC) of EAECA and BECA are recorded at 125.24±10.14 and 53.03±2.50 mgGAE/g extract, respectively. Both extracts revealed the antioxidant activity in a concentration-dependent manner; this effect is more pronounced with EAECA. The BECA exhibited a higher anti-inflammatory activity. This anti-inflammatory activity was reflected in a reduction of swelling of carrageenan-evoked edemas (48.45 %), inhibition of nitric oxide (84.7 %), effective decrease in myeloperoxidase activity (58.82 %) and malondialdehyde level (65.58 %). The cytotoxic effect of BECA was found to be more pronounced against C6 cell lines (IC50 value: 131.93 µg/mL) while the cytotoxic activity of EAECA was more effective against HT29 and OV2008 cell lines. Conclusion: The obtained results indicated that EAECA exhibited a high antioxidant activity, while BECA has significant anti-inflammatory activity. Both extracts showed cytotoxic effects against cancer cell lines at certain concentrations in a cell-specific manner. |
| Anahtar Kelimeler |
| Anti-inflammatory activity | Antioxidant activity | Antiproliferative activity | Centaurea africana | Flavonoids | Oxidative stress | Phenolic content |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 8 |
| Google Scholar | 9 |