Single-Cell Epigenomics In Cancer Research
Yazarlar (2)
Dr. Öğr. Üyesi Çağlar BERKEL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ercan ÇAÇAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | Diğer hakemli uluslararası dergilerde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Biomedical Journal of Scientific Technical Research |
| Dergi ISSN | 2574-1241 |
| Dergi Tarandığı Indeksler | Crossref |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2019 |
| Cilt No | 21 |
| Sayı | 3 |
| DOI Numarası | 10.26717/BJSTR.2019.21.003619 |
| Makale Linki | https://biomedres.us/fulltexts/BJSTR.MS.ID.003619.php |
| Özet |
| A single tumor mass is comprised of many different subpopulations of cells. During evolutionary trajectory of a tumor, cells with different molecular features are likely to evolve and interactions between these heterogenous cell subpopulations in tumor are highly dynamic [1]. This intratumoral heterogeneity (ITH) is regulated in multiple levels and each cell subpopulation in a particular tumor can have distinct genomic, epigenomic, transcriptomic and spatial characteristics, effecting their metastatic potential and chemoresistance [2]. How the complex contributions of each subgroup in a complete population of cells in tumor affects the clinical progression of the disease is not completely understood. This is mostly due to the fact that cancer research previously has been limited to the analysis of bulk cells without dissecting heterogenous cell populations into subgroups with similar molecular features, therefore these studies have only reflected average profile of complex subgroups of cells, called subclones. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 4 |