Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease
Yazarlar (6)
Gül Dursun
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Prof. Dr. Helin DENİZ DEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman DEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | European Journal of Rheumatology | ||
| Dergi ISSN | 2147-9720 | ||
| Dergi Tarandığı Indeksler | ESCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2018 |
| Cilt / Sayı / Sayfa | 5 / 1 / 27–31 | DOI | 10.5152/eurjrheum.2017.16102 |
| Makale Linki | http://www.eurjrheumatol.org/eng/makale/3059/213/Full-Text | ||
| UAK Araştırma Alanları |
Göz Hastalıkları
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| Özet |
| Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population. One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed using Statistical Package for Social Sciences (SPSS) 22.0 (IBM Corp.; Armonk, NY, USA) (p<0.05). The genotype distribution and allele frequencies of the IL-1Ra VNTR variant did not differ significantly between the patients and the controls (p>0.05). The frequency of the a1/a1, a1/a2 genotypes and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26, and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1Ra VNTR variant genotypes and clinical characteristics (p>0.05). The results of this study do not support an association between the IL-1Ra VNTR variant and the risk of BD in a Turkish population. However, further studies of this variant with larger sample sizes and different ethnicities are required for confirmation. |
| Anahtar Kelimeler |
| Behçet’s disease | interleukin 1 receptor antagonist | variable number tandem repeat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 1 |