Antioxidant status and levels of antioxidant vitamins in coronary artery ectasia
Yazarlar (11)
Fatih Koç Akdeniz Üniversitesi, Türkiye
Nihat Kalay Erciyes Üniversitesi, Türkiye
İdris Ardıç Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Kerem Özbek Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Köksal Ceyhan
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Hasan Kadı
Balıkesir Üniversitesi, Türkiye
Balıkesir Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Altunkaş
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Orhan Önalan Karabük Üniversitesi, Türkiye
Mehmet Güngör Kaya Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CORONARY ARTERY DISEASE (Q4) | ||
| Dergi ISSN | 0954-6928 Dergi Bilgileri (2011) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2011 |
| Cilt / Sayı / Sayfa | 22 / 5 / 306–310 | DOI | 10.1097/MCA.0b013e328346b864 |
| Makale Linki | https://www.ovid.com/jnls/coronary-artery/abstract/10.1097/mca.0b013e328346b864~antioxidant-status-and-levels-of-antioxidant-vitamins-in?redirectionsource=fulltextview | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Coronary artery ectasia (CAE) is a rare coronary artery anomaly. In this study, we investigated superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and γ-glutamyltransferase (GGT) activities, and antioxidant vitamin levels (vitamins A and E) in patients with CAE. Forty-five patients who were diagnosed with CAE using coronary angiography were included in the study (26 men; mean age, 57 ± 9 years). The control group consisted of 35 participants who had normal coronary arteries as shown by coronary angiography (14 men; mean age, 54 ± 7 years). The plasma activity of SOD, GSH-Px, GGT, and levels of vitamins A and E were measured. The plasma SOD activity was significantly lower in the CAE group compared with the control group (0.70 ± 0.64 vs. 1.52 ± 0.85 U/ml; P=0.001). The serum GGT activity was higher in the CAE group compared with the control group (34 ± 20 vs. 26 ± 13 U/ml; P=0.04). There were no significant differences in the plasma GSH-Px activity and vitamin A and E levels. There was a positive correlation between SOD activity and low-density lipoprotein cholesterol levels (r=0.418; P=0.01). There was also a positive correlation between vitamin E and low-density lipoprotein cholesterol (r=0.410; P=0.01) and triglyceride levels (r=0.310; P=0.04) in patients with CAE. In this study, patients with CAE had a decreased SOD plasma activity and an increased GGT activity compared with normal controls. These results suggest that oxidative stress and antioxidant status may have an important role in the pathogenesis of CAE. |
| Anahtar Kelimeler |
| c-glutamyltransferase coronary artery ectasia | glutathioneperoxidase | superoxide dismutase | vitamins A and E |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Web of Science | 9 |