The protective effect of single dose tadalafil in contrast induced nephropathy An experimental study
Yazarlar (9)
Özbek Kerem
Köksal Ceyhan
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Koç Akdeniz Üniversitesi, Türkiye
Erkan Söğüt
İzmir Katip Çelebi Üniversitesi, Türkiye
İzmir Katip Çelebi Üniversitesi, Türkiye
Fatih Altunkaş
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hasan Kadı
Balıkesir Üniversitesi, Türkiye
Balıkesir Üniversitesi, Türkiye
Prof. Dr. Reşit Doğan KÖSEOĞLU Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Orhan Önalan Karabük Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | ANATOLIAN JOURNAL OF CARDIOLOGY (Q4) | ||
| Dergi ISSN | 2149-2263 Dergi Bilgileri (2015) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2015 |
| Cilt / Sayı / Sayfa | 15 / 4 / 306–310 | DOI | 10.5152/akd.2014.5380 |
| Makale Linki | http://anatoljcardiol.com/jvi.aspx?un=AJC-38632 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Contrast-induced nephropathy (CIN) is one of the most common causes of acute renal failure in hospitalized patients. The direct toxic effect of contrast media; ischemic damage caused by reactive oxygen species; increased perivascular hydrostatic pressure; high viscosity and changes in the activity of vasoactive substances play important roles in the pathogenesis. Tadalafil inhibits the phosphodiesterase enzyme which destroys nitric oxide. Nitric oxide causes renal vasodilatation, increases renal medullar blood flow and mediates the removal of free oxygen radicals. Drugs that increase levels of nitric oxide are expected to reduce the development of contrast nephropathy due to contrast media. We aimed to test the hypothesis that tadalafil reduces the development of contrast nephropathy due to contrast toxicity. A total of 24 female Wistar albino rats, three groups of eight, were included in the study. After 48 hours of dehydration, contrast media (meglumine diatrozoate, 6 mL/kg) was administered to the first group, and contrast media with tadalafil (10 mg/kg) was administered to the second group. The third group served as the control group. Blood and tissue samples were taken 48 hours after this procedure. Serum cystatin C, serum creatinine and blood urea nitrogen (BUN) values were significantly lower in the contrast with tadalafil group compared to the group given only contrast. Serum and tissue malondialdehyde (MDA) levels were significantly lower in the contrast with tadalafil group than in the contrast only group. These results demonstrate the protective effect of tadalafil in the prevention of CIN in rats. |
| Anahtar Kelimeler |
| contrast-induced nephropathy | nitric oxide | tadalafil | phosphodiesterase-5 inhibitors | cystatin C |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 11 |
| Web of Science | 17 |
| TR Dizin | 2 |