Analyses of C Reactive Protein Endothelial Nitric Oxide Synthase and Interleukin 6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease A Pilot Study
Yazarlar (11)
Prof. Dr. Ataç ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mustafa Özçetin T.C. Sağlık Bakanlığı, Türkiye
Prof. Dr. Hacı Ömer ATEŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Altunkaş
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Kayıhan KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İlker Akar Gaziosmanpaşa Üniversitesi, Türkiye
İlker İnce Gaziosmanpaşa Üniversitesi, Türkiye
Murat Yalçın T.C. Sağlık Bakanlığı, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Köksal Ceyhan
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Koç Akdeniz Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BALKAN MEDICAL JOURNAL (Q4) | ||
| Dergi ISSN | 2146-3123 Dergi Bilgileri (2015) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2015 |
| Cilt / Sayı / Sayfa | 32 / 4 / 397–402 | DOI | 10.5152/balkanmedj.2015.151190 |
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Background: Family history of premature atheroscle-rosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and In-terleukin-6 (IL-6) has shown in previous studies.Aims: The major aim of the study was to evaluate the CRP, eNOS, and IL-6 gene polymorphisms in a group of adolescents who have a parental history of early cor-onary artery disease (CAD).Study Design: Case-control study.Methods: Thirty-six volunteers with a father with obstructive CAD during the first four decades and 46 subjects with a father with normal coronary arteries documented with coronary angiography were includ-ed in the study. Polymerase chain reaction-restriction fragment length polymorphism techniques were used to analyze CRP, eNOS, and IL-6 polymorphisms.Results: We did not find any differences between the two groups with regard to age, sex, body mass index, renal func-tions, systolic and diastolic blood pressures, lipid profile, and fasting glucose, hemoglobin, and high sensitivity CRP. A significant difference was only observed in IL-6-572 G/C genotype distribution and allele frequency between two groups (Pc=0.036 OR=3.48 CI (95%) 1.17-10.32).Conclusion: The present study showed a significant association between the IL-6-572 G/C gene polymor-phism (presence of C allele) and adolescents with a pa-rental history of premature CAD |
| Anahtar Kelimeler |
| Atherosclerosis | C-reactive protein | polymorphism | nitric oxide synthase | interleukins |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 3 |
| Web of Science | 6 |
| TR Dizin | 2 |