Cardiotrophin 1 plasma levels are increased in patients with diastolic heart failure
Yazarlar (10)
Prof. Dr. Ataç ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Şemsettin Şahin
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Koç Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Mehmet Şahin Gaziosmanpaşa Üniversitesi
İsmail Benli
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Hasan Kadı
Balıkesir Üniversitesi, Türkiye
Balıkesir Üniversitesi, Türkiye
Turgay Burucu Gaziosmanpaşa Üniversitesi, Türkiye
Köksal Ceyhan
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ünal Erkorkmaz Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MEDICAL SCIENCE MONITOR (Q3) | ||
| Dergi ISSN | 1643-3750 Dergi Bilgileri (2012) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 18 / 1 / – | DOI | 10.12659/MSM.882197 |
| Makale Linki | http://www.medscimonit.com/medscimonit/index.php | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in various cardiovascular diseases, including chronic heart failure. The aim of the study was to determine if plasma CT-1 is associated with diastolic heart failure (DHF) and to investigate the relationship between CT-1 and echocardiographic parameters. Fifty-seven consecutive patients (mean age 57 ± 8 years, 24 males) diagnosed with DHF in our clinic and 33 controls (mean age 55 ± 7 years, 12 males) were included in the study. All study participants underwent echocardiographic evaluation and blood samples were obtained. CT-1 and NT-proBNP values were significantly higher in DHF subjects than in controls (11.30 [8.09-16.51] vs. 17.5 [8.95-28.74] fmol/mL, P=0.017 and 64 [27.5-95] vs. 82 [55.5-241] pg/mL, P=0.009, respectively). The mitral peak velocity of early diastolic filling (E), mean ratio of E to early diastolic mitral annular velocity (E/Em), and the pulmonary capillary wedge pressure (PCWP) estimated from E/Em measurements were all significantly higher in the patient group (62.27 ± 14.69 vs. 75.67 ± 18.85 cm/sec, 6.40 ± 1.48 vs. 10.30 ± 3.48, and 10 [9-11] vs. 14[12-16] mmHg, P ≤ 0.001 for all). Lateral and septal Em were significantly lower in the patient group (10.69 ± 1.87 vs. 8.69 ± 2.00 cm/sec and 8.91 ± 1.22 vs. 6.65 ± 1.58 cm/sec, P<0.001 for both). CT-1 positively correlated with NT-proBNP (P=0.001, r=0.349), mean E/Em (P=0.003, r=0.307), and estimated mean PCWP (P=0.001, r=0.308). CT-1 is elevated in patients with DHF and is associated with NT-proBNP and estimated left ventricular filling pressures. |
| Anahtar Kelimeler |
| Cardiotrophin-1 • diastolic heart failure • tissue Doppler echocardiography • N-terminalpro-B-type natriuretic peptide |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 13 |
| Web of Science | 18 |