Sodium Bicarbonate Versus Isotonic Saline for the Prevention of Contrast Induced Nephropathy in Patients With Diabetes Mellitus Undergoing Coronary Angiography and or Intervention A Multicenter Prospective Randomized Study
Yazarlar (10)
Fatih Koç Akdeniz Üniversitesi, Türkiye
Kurtuluş Özdemir Necmettin Erbakan Üniversitesi, Türkiye
Fatih Altunkaş
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI Gaziosmanpaşa Üniversitesi, Türkiye
Enes Elvin Gül
Prof. Dr. Ünal Erkorkmaz Sakarya Üniversitesi, Türkiye
Hasan Kadı
Balıkesir Üniversitesi, Türkiye
Balıkesir Üniversitesi, Türkiye
Mahmut Akpek Adnan Menderes Üniversitesi, Türkiye
Mehmet Güngör Kaya Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF INVESTIGATIVE MEDICINE (Q2) | ||
| Dergi ISSN | 1081-5589 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2013 |
| Cilt / Sayı / Sayfa | 61 / 5 / 872–877 | DOI | – |
| Makale Linki | https://journals.sagepub.com/doi/10.2310/JIM.0b013e31828e9cab?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Contrast-induced nephropathy (CIN) is a leading cause of acute renal failure and affects mortality and morbidity. Although the incidence of CIN is quite low in the general population, CIN incidence is significantly increased in patients with diabetes mellitus (DM). We compared the efficacy of prophylactic use consisting of a saline infusion or a sodium bicarbonate infusion for the prevention of CIN in patients with DM. A total of 195 DM patients who had unselected renal function were randomized into 2 groups: 101 patients were assigned to saline infusion, and 94 patients were assigned to bicarbonate infusion. The primary end point was the maximum increase in the serum creatinine (SCr) level, whereas the secondary end point was the development of CIN after the procedure. The maximum increase in SCr levels was significantly lower in the saline group than in the bicarbonate group: -0.03 mg/dL (IQR, -0.09 to 0.10 mg/dL) versus 0.02 mg/dL (IQR, -0.09 to 0.13 mg/dL) (P = 0.014). The rate of CIN was significantly lower in the saline group than in the bicarbonate group (5.9% vs 16%, P = 0.024). In the subset of study participants with a baseline creatinine clearance of less than 60 mL/min, the maximum increase in SCr levels was significantly lower, -0.08 mg/dL (IQR, -0.13 to -0.04 mg/dL), in the saline group than in the bicarbonate group, 0.03 mg/dL (IQR, -0.13 to 0.12 mg/dL) (P = 0.004). The use of prophylactic hydration with isotonic saline before coronary procedures may decrease SCr levels and reduce the incidence of CIN in patients with DM with unselected renal functions to a greater extent than sodium bicarbonate can. |
| Anahtar Kelimeler |
| contrast-induced nephropathy | diabetes mellitus isotonic saline | sodium bicarbonate |
