Theeffect of diet induced obesity on testicular tissue and serum oxidative stressparameters
Yazarlar (6)
University Gaziosmanpasa, Türkiye
Prof. Dr. Doğan ATILĞAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
University Gaziosmanpasa, Türkiye
University Gaziosmanpasa, Türkiye
University Gaziosmanpasa, Türkiye
University Gaziosmanpasa, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Actas Urologicas Espanolas |
| Dergi ISSN | 0210-4806 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2012 |
| Cilt No | 36 |
| Sayı | 3 |
| Sayfalar | 153 / 159 |
| DOI Numarası | 10.1016/j.acuro.2011.06.019 |
| Özet |
| Objective: The aim of this study was to evaluate the effects of diet induced obesity on semen parameters and serum antioxidant enzyme levels. Material and methods: Six-week-old male rats were randomized into three groups are as follows: group 1 (n = 10) received a control diet, group 2 (n = 9) received a high-fat diet and group 3 (n = 11) received high-fat diet plus anastrozole. At the completion of a 10-week period, testicular tissues were obtained and spermatogenesis was evaluated with Johnsen Score System. The normal Johnsen Score was accepted as >9.39. In addition, serum antioxidant enzyme levels, triglyceride, cholesterol, testosterone, luteinizing hormone (LH), follicle stimilating hormone (FSH) and estradiol levels were measured in serum. Results: Body weight were significantly increased in mice fed with a high-fat diet compared to normal diet (P <.05). The mean triglyceride levels was 64.00 ± 20.48 mg/dl, 98.89 ± 27.80 mg/dl and 95.27 ± 15.02 mg/dl in group 1, group 2 and group 3, respectively (P <.05). Male rats fed with a high-fat diet had significantly lower levels of testosterone compared with the control diet male rats (P =.005). Testicular pathology revealed that Johnsen Score System were 9.60 ± 0.15, 8.72 ± 1.81 and 9.29 in group 1, group 2 and group 3, respectively (P =.169). In addition serum nitric oxide (NO) levels were higher in group 2 and group 3 compared to group 1 (P <.05). Conclusion: As a result it may be concluded that obesity may induce oxidative stress and decrease testosterone levels. These changes may alter testicular functions and consequently it may be speculated that obesity can be important causative factor in the etiology of the male infertility. © 2011 AEU. Published by Elsevier España, S.L. All rights reserved. |
| Anahtar Kelimeler |
| Anastrazole | Male infertility | Obesity | Oxidative stress | Testosterone |
Science Direct
Theeffect of diet induced obesity on testicular tissue and serum oxidative stressparameters
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 68 |
| SCOPUS | 82 |
| Google Scholar | 130 |
| Google Scholar | 9 |