An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis
Yazarlar (7)
Prof. Dr. Nihat ULUOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Doğan ATILĞAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret ERDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bekir S. Parlaktas
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Adem Yasar Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Unal Erkorkmaz Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali Akbas Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Urology and Nephrology (Q4) | ||
| Dergi ISSN | 0301-1623 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2010 |
| Cilt / Sayı / Sayfa | 42 / 4 / 889–895 | DOI | 10.1007/s11255-010-9706-y |
| Özet |
| This experimental study was designed to produce ischemia–reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters. Twenty-one adult male rats were randomly divided into three groups as follows; sham operated, control group (Group C): only penectomy was performed and blood (3 ml) drawn from vena cava inferior (VCI), ischemia and reperfusion group (Group I/R); priapism (1 h) + ½ h reperfusion + penectomy + blood from VCI, melatonin treatment group (Group I/R + M); priapism (1 h) + melatonin (½ h before reperfusion, 50 mg/kg, ip) + ½ h reperfusion + penectomy + blood from VCI. Priapism was induced with a vacuum erection device (cut tip of 2-cc syringe) and a rubber band was placed at the base of the erect penis. In two groups, excluding Group C, penectomies were performed after 1 h of ischemic … |
| Anahtar Kelimeler |
| Antioxidants | Ischemic priapism | Melatonin | Reperfusion injury |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 30 |
| Scopus | 3 |
| Web of Science | 18 |